selective cyclization and is omerization of 3-propargylthio- 1,2,4- benzotriazine to thiazolo [2,3-c] [1,2,4] benzotriazine
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abstract
the method cited in the literature for synthesis of 1,2- dihydro 3- thioxo - 1,2,4- benzotriazine 1 was improved .1 was condensed with propargyl bromide to afford 3 - propargylthio – 1,2,4 -benzotriazine 5. transformation of this compound to 9h-3- methylthiazolo [2,3-c] [1,2,4] benzotriazine ( 3, r = me) was performed in the presence of na o me / meoh . orientation of this selective cyclization was ascertained by (n.o.e.) nmr experiment
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Journal title:
journal of sciences islamic republic of iranجلد ۱۰، شماره ۱، صفحات ۰-۰
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